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Glucose-dependent spatial and temporal modulation of oligodendrocyte progenitor cell proliferation via ACLY-regulated histone acetylation

S. Sauma, S. Stransky, I. Selcen, S. Sidoli, R. Abzalimov, Y. He, P. Casaccia. Glucose-Dependent Spatial and Temporal Modulation of Oligodendrocyte Progenitor Cell Proliferation via ACLY-Regulated Histone Acetylation. Nat Neurosci, 2026, 1–15. DOI: https://doi.org/10.1038/s41593-026-02263-7.

A Climate BioStress Sentinel System: Identifying climate impacts from the genome to the urbanized biosphere

C.J. Vörösmarty, M. Trujillo, P. Casaccia, A. Cak, K.H. Gardner, D.I. Greenfield, P.M. Groffman, A. Reinmann, W. Solecki, M. Serreze, J. Waldman, J.M. Bhatnagar, H. Brumberg, A. Carnaval, J. Cullmann, S.P. Egendorf, M.E. Hauber, J. Herlan, I. Kavouras, C.E. Mason, P. Marcotullio, M. McCracken, D.A. McKay, F. Miszlivetz, T. Muth, Y. Nomura, C.A. Penick, J. Rising, R. Toledo-Crow, and C. Zarnoch. A Climate BioStress Sentinel System: Identifying climate impacts from the genome to the urbanized biosphere. Cell Reports Sustainability, 2025, 2, 100558.

HP1α forms multiphase condensates with DNA and TERRA

Telomeric RNA and HP1α form interfacial clusters that stabilize HP1α-DNA condensates

P. Deshpande, A. Geissmann, H.-J. Park, J. Liu, P. Casaccia, S. Elbaum-Garfinkle. Telomeric RNA and HP1α Form Interfacial Clusters That Stabilize HP1α-DNA Condensates. Commun Biol, 2025. DOI: https://doi.org/10.1038/s42003-025-09173-7.

The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and Cell Death in Oligodendrocyte Progenitors

M. Pruvost, H.-J. Park, C. Habermacher, M. Li, M. C. Angulo, J. Liu, P. Casaccia. The Histone Methyltransferases EHMT1 and EHMT2 Repress the Expression of Genes Related to Excitability and Cell Death in Oligodendrocyte Progenitors. Glia, 2025. DOI: https://doi.org/10.1002/glia.70014.

Neuroprotective Effect of Neuron‐specific Deletion of the C16 Ceramide Synthetic Enzymes in an Animal Model of Multiple Sclerosis

M. Amatruda, D. Marechal, M. Gacias, M. Wentling, S. Turpin‐Nolan, J. Morstein, M. Moniruzzaman, J. C. Brüning, N. J. Haughey, D. H. Trauner, P. Casaccia. Neuroprotective Effect of Neuron‐specific Deletion of the C16 Ceramide Synthetic Enzymes in an Animal Model of Multiple Sclerosis. Glia, 2024, glia.24631. DOI: https://doi.org/10.1002/glia.24631.

PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation

D. Huang, A. Mela, N. V. Bhanu, B. A. Garcia, P. Canoll, P. Casaccia. PDGF-BB Overexpression in P53 Null Oligodendrocyte Progenitors Increases H3K27me3 and Induces Transcriptional Changes Which Favor Proliferation. Neoplasia, 2024, 57, 101042. DOI: https://doi.org/10.1016/j.neo.2024.101042.

Histone H4 Acetylation Differentially Modulates Proliferation in Adult Oligodendrocyte Progenitors

D. K. Dansu, I. Selcen, S. Sauma, E. Prentice, D. Huang, M. Li, S. Moyon, P. Casaccia. Histone H4 Acetylation Differentially Modulates Proliferation in Adult Oligodendrocyte Progenitors. Journal of Cell Biology, 2024, 223 (11), e202308064. DOI: https://doi.org/10.1083/jcb.202308064.

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